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-synuclein, that is a primary component of Lewy bodies, in PARK 1 in 1997 and parkin in PARK 2 in 1998, which can be an E3 ubiquitin ligase and results in endoplasmic reticulum (ER) tension, suggest that dysfunction in the intracellular proteinase units, like ubiquitin-proteasome program or lysosomal technique, which gets rid of pointless toxic pro

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